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UID:20250928T193646EDT-9139joBWcS@132.216.98.100
DTSTAMP:20250928T233646Z
DESCRIPTION:Dr. Jennifer Estall\n	IRCM - Montreal Clinical Research Institut
 e\n\n \n\n'Balancing metabolic and inflammatory responses in the liver'\n
 \nLiver is regularly exposed to ever-changing metabolic and inflammatory e
 nvironments. It must sense and adapt to energy need while balancing resour
 ces required to protect itself from insult. Peroxisome proliferator-activa
 ted receptor gamma coactivator 1-alpha (PGC-1α) is a transcriptional coact
 ivator that both coordinates metabolic adaptation to diverse stimuli and p
 rotects against inflammation. Using cell and animal models\, we are invest
 igating mechanistic links between this transcriptional regulator and metab
 olic diseases. Low levels of PGC-1α in liver are associated with hepatic s
 teatosis and insulin resistance\, hallmarks of fatty liver disease and the
  metabolic syndrome. We are investigating how the PGC-1α coactivator famil
 y controls the liver’s response to insulin\, while simultaneously coordina
 ting genes programs of mitochondrial metabolism and inflammation in hepato
 cytes. We hope that delineating the complex biology of PGC-1α in cells wil
 l help to better understand the consequences of disrupted PGC-1α activity 
 in metabolic disease.\n
DTSTART:20191113T163000Z
DTEND:20191113T173000Z
LOCATION:1/12\, Strathcona Anatomy and Dentistry Building\, CA\, QC\, Montr
 eal\, H3A 0C7\, 3640 rue University
SUMMARY:Departmental Seminar: Jennifer Estall
URL:/anatomy/channels/event/departmental-seminar-jenni
 fer-estall-300464
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