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UID:20250929T184550EDT-9827JnpP3F@132.216.98.100
DTSTAMP:20250929T224550Z
DESCRIPTION:Nature’s extraordinary elegance when performing chemical reacti
 ons has fascinated and inspired chemists for decades. Arguably\, one of th
 e most complex organic transformations performed in living organisms\, is 
 the tail-to-head terpene (THT) cyclization.[1\,2] It allows the constructi
 on of the most diverse class of natural products\, namely terpenes\, via n
 ature’s way of combinatorial chemical synthesis. Thousands of different na
 tural products are formed from just a handful of simple\, acyclic starting
  materials: geranyl pyrophosphate (monoterpenes)\, farnesyl-PP (sesquiterp
 enes) and geranylgeranyl-PP (diterpenes). Nature utilizes enzymes\, termed
  cyclases or terpene synthases\, to carry out this complex transformation.
  Building upon our initial results\,[3\,4\,5] we explore possibilities to 
 utilize supramolecular structures to mimic such complex transformations in
  the laboratory. The latest results in this direction will be presented.\n
 \n[1]     S. V. Pronin\, R. A. Shenvi Nature Chem. 2012\, 4\, 915. [2]    
   D. J. Miller\, R. K. Allemann Nat. Prod. Rep. 2012\, 29\, 60. [3] Q. Zha
 ng\, K. Tiefenbacher J. Am. Chem. Soc. 2013\, 135\, 16213. [4] Q. Zhang\, 
 K. Tiefenbacher Nature Chem. 2015\, 7\, 197. [5] Q. Zhang\, L. Catti\, J. 
 Pleiss\, K. Tiefenbacher J. Am. Chem. Soc. 2017\, 139\, 11482.\n
DTSTART:20180606T150000Z
DTEND:20180606T163000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Professor Konrad Tiefenbacher - Terpene B
 iosynthesis as Inspiration for Supramolecular Catalysis
URL:/chemistry/channels/event/chemical-society-seminar
 -professor-konrad-tiefenbacher-terpene-biosynthesis-inspiration-286946
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