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UID:20250929T125826EDT-1383EWP5NC@132.216.98.100
DTSTAMP:20250929T165826Z
DESCRIPTION:Although natural products have traditionally played an importan
 t role in therapeutic discovery and development\, rediscovery of known com
 pound classes is increasingly hampering novel compound development. 1 To a
 ddress this issue\, our laboratory is developing new methods for the direc
 t mechanistic and chemical characterization of small molecules in complex 
 mixtures. 2 Using a combination of multi-parametric high-throughput screen
 ing assays that report on compound modes of action\, and untargeted metabo
 lomics methods that describe the chemical complexity of natural products s
 amples\, we are creating pipelines for novel bioactive compound discovery.
  3 These methods employ statistical methods to relate the presence or abse
 nce of compounds and compound classes to the presence or absence of specif
 ic phenotypes on screening libraries\, providing a mechanism for the direc
 t chemical and phenotypic profiling for all bioactive constituents from an
 y natural products mixture. Recent results from this new platform will be 
 presented.\n\n \n\n(1) Pye\, C. R.\; Bertin\, M. J.\; Lokey\, R. S.\; Gerw
 ick\, W. H.\; Linington\, R. G. Proc. Natl. Acad. Sci. U.S.A. 2017\, 114 (
 22)\, 5601.\n\n(2) Ochoa\, J. L.\; Sanchez\, L. M.\; Koo\, B.-M.\; Doherty
 \, J. S.\; Rajendram\, M.\; Huang\, K. C.\; Gross\, C. A.\; Linington\, R.
  G. ACS Infect. Dis. 2018\, 4 (1)\, 59.\n\n(3) Kurita\, K. L.\; Glassey\, 
 E.\; Linington\, R. G. P. Natl. Acad. Sci. U.S.A. 2015\, 112 (39)\, 11999.
 \n
DTSTART:20181030T170000Z
DTEND:20181030T183000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Roger Linington - Integrated Methods for 
 Bioactive Natural Product Discovery 
URL:/chemistry/channels/event/chemical-society-seminar
 -roger-linington-integrated-methods-bioactive-natural-product-discovery-28
 9280
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