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UID:20250929T125950EDT-8114xSWO8N@132.216.98.100
DTSTAMP:20250929T165950Z
DESCRIPTION:Abstract:\n\nMolecular biology is messy and complex. The future
  of life sciences research\, drug development\, and many other fields depe
 nds on our ability to unravel the complex\, molecular phenomena that under
 lie cellular function. Using currently available technologies\, it is stil
 l challenging and costly to conduct single-molecule measurements that can 
 potentially reveal the true complexity of life at the molecular scale. Con
 vex Lens-induced Confinement (CLiC) microscopy is a simple\, general metho
 d of imaging molecular interactions one molecule at a time. By mechanicall
 y confining molecules to the field of view\, CLiC eliminates the complexit
 y and potential biases inherent in methods such as optical tweezers and TI
 RF. In this talk I discuss how we employ CLiC to investigate how DNA super
 coiling regulates the dynamic unwinding of specific target sites\, and the
  activity of molecules binding to these sites – important biophysical ques
 tions for medicine and antisense oligonucleotide drug development (Scott e
 t. al.\, Nucleic Acids Research 2018). I will also introduce new and emerg
 ing areas of exploration with CLiC including protein droplets\, nanopartic
 le dynamics\, CRISPR-Cas9 search processes\, and therapeutics applications
 .\n\nBio:\n\nDr. Sabrina Leslie is an Associate Professor of Physics and Q
 uantitative Life Sciences at 91Ö±²¥. She founded her single-mol
 ecule imaging laboratory in 2012\, where she has pioneered new techniques 
 to shed light into the elusive and complex interactions and dynamics of ma
 cromolecules. Her academic training began in 1998 as an undergraduate at U
 BC\, where she graduated from the Combined Honours Physics and Mathematics
  Program\, as a Canada Scholar and recipient of the CK Choi Presidential A
 ward. In 2002\, she moved to UC Berkeley as an NSERC fellow to pursue doct
 oral studies in optical physics. In 2009\, she transitioned from visualizi
 ng hard to soft materials\, focusing on biomolecules in liquids. This tran
 sition to the Department of Chemistry and Chemical Biology at Harvard Univ
 ersity was made possible with a Mary Fieser post- doctoral fellowship\, wi
 th the mandate to explore her passion for imaging in a health sciences con
 text. At Harvard\, she invented a single-molecule imaging technology calle
 d Convex Lens-induced Confinement (CLiC)\, which established her as a pion
 eer in single-molecule investigations with a range of applications. To exp
 and and commercialize her technology and basic research ideas\, she has re
 cently co-founded a start-up company\, ScopeSys\, which has business offic
 es in Montreal and Vancouver.\n
DTSTART:20190108T180000Z
DTEND:20190108T193000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Sabrina Leslie - Deconstructing biology w
 ith simple single-molecule imaging: Controlling conformation\, confinement
 \, and concentration
URL:/chemistry/channels/event/chemical-society-seminar
 -sabrina-leslie-deconstructing-biology-simple-single-molecule-imaging-2924
 72
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