BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250929T072109EDT-7721x6VBWS@132.216.98.100 DTSTAMP:20250929T112109Z DESCRIPTION:Abstract:\n\nTraditional strategies for development of chemosel ective imaging reagents rely on molecular recognition and static lock-and- key binding to achieve high specificity. We are advancing an alternative a pproach to chemical probe design\, termed activity-based sensing (ABS)\, i n which we exploit inherent differences in chemical reactivity as a founda tion for distinguishing between chemical analytes that are similar in shap e and size within complex biological systems. This presentation will focus on ABS approaches to develop new fluorescent probes for transition metals and reactive oxygen\, sulfur\, and carbon species and their signal/stress contributions to living systems\, along with activity-based proteomics to identify novel targets and pathways that these emerging classes of chemic al signals regulate.\n\nBio:\n\nChris Chang is the Class of 1942 Chair Pro fessor of Chemistry and Molecular and Cell Biology and HHMI Investigator a t UC Berkeley\, as well as a Faculty Scientist in the Chemical Sciences Di vision of Lawrence Berkeley National Laboratory. He was born in Ames\, IA and completed his B.S. and M.S. degrees from Caltech in 1997\, working wit h Prof. Harry Gray on spectroscopy of metal-nitrido and metal-oxo complexe s. After spending a year as a Fulbright scholar in Strasbourg\, France wit h Nobel Laureate Dr. Jean-Pierre Sauvage on chemical topology\, Chris earn ed his Ph.D. from MIT in 2002 under the supervision of Prof. Dan Nocera\, where his graduate work focused on proton-electron transfer and oxygen cat alysis. He stayed at MIT as a Jane Coffin Childs postdoctoral fellow with Prof. Steve Lippard\, working on zinc biology and then began his independe nt career at UC Berkeley in 2004. \n\nResearch in the Chang group focuses on the study of metals in biology and energy\, with particular interests i n neuroscience\, metabolism\, and solar-to-chemical conversion. His lab ha s made fundamental discoveries in inorganic and biological chemistry throu gh developing activity-based sensing probes to open a field of transition metal signaling\, exemplified by identifying copper and hydrogen peroxide signals that regulate processes spanning neural activity to fat metabolism . The discovery of copper-mediated signaling establishes a new paradigm fo r metals in biology\, expanding the roles of redox transition metals beyon d metabolic cofactors. Chang's lab has also advanced artificial photosynth esis through bioinorganic catalyst design. His group's work in catalysis h as shown that simple molecular mimics of complex enzymes and materials can be used to create new classes of catalysts for solar hydrogen production that feature cheap\, earth-abundant elements and operate under environment ally friendly conditions. More recent efforts have established a broad-bas ed program in hybrid catalysis to mimic and interface with biological and materials systems. Chang has published over 180 papers with an average of 110 citations per paper (h-index 87)\, with over 10 awarded patents\, and has given over 300 invited lectures worldwide. His group's research has be en honored by awards from the Dreyfus\, Beckman\, Sloan\, and Packard Foun dations\, Amgen\, Astra Zeneca\, and Novartis\, AFAR\, MIT Technology Revi ew (TR35 Award)\, ACS (Cope Scholar\, Eli Lilly Award in Biological Chemis try\, Baekeland Award)\, RSC (Transition Metal Chemistry)\, and the Societ y for Biological Inorganic Chemistry. Most recent honors include the 2013 Noyce Prize at UC Berkeley for Excellence in Undergraduate Teaching\, the 2015 Blavatnik National Award in Chemistry\, the 2018 RSC Jeremy Knowles A ward\, the 2019 Sackler Prize in Chemistry\, and election to the American Academy of Arts and Sciences. More information on the Chang lab can be fou nd at http://www.cchem.berkeley.edu/cjcgrp/ .\n\n \n DTSTART:20190402T170000Z DTEND:20190402T183000Z LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\ , 801 rue Sherbrooke Ouest SUMMARY:Chemical Society Seminar: Chris Chang - Activity-Based Sensing Appr oaches to Decipher Transition Metal Signaling URL:/chemistry/channels/event/chemical-society-seminar -chris-chang-activity-based-sensing-approaches-decipher-transition-metal-2 93039 END:VEVENT END:VCALENDAR