BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250928T231343EDT-9019R91AGb@132.216.98.100 DTSTAMP:20250929T031343Z DESCRIPTION:Zoom link: https://mcgill.zoom.us/j/93138916610\n\nAbstract:\n \nProtein-based materials represent sustainable and easily customizable al ternatives to conventional synthetic polymers. With their biocompatibility \, bioactivity and genetic tunability\, proteins can be customized for a r ange of biomedical applications. Specifically\, protein materials that sel f-assemble into macromolecular structures and can be produced at large sca le are of interest for deployment into wearable devices and tissue scaffol ds. Curli fibers produced by Escherichia coli bacteria represent a very pr omising protein scaffold due to their unique physicochemical properties. O nce secreted by bacteria cells\, CsgA subunits\, the self-assembling repea ts of curli fibers\, form fibrous structures that can further aggregate an d gel into macroscopic materials.\n\nIn this talk\, I will describe advanc es from our group to engineer curli fibers and confer them with properties relevant for biomedical and biosensing devices. First\, I will present a strategy to fabricate wearable sensors made of genetically engineered curl i fibers embedded in a textile matrix. Second\, I will describe how the se lf-assembly mechanism of curli fibers can be utilized to drive the assembl y of small peptides into supramolecular materials. Among other functionali ties\, we have genetically encoded in CsgA the ability to fluoresce in res ponse to pH changes\, and the ability to nucleate mineral particles. These functional protein constructs serve as proof-of-concept for the developme nt of biocompatible scaffolds and sensing platforms and expand the diversi ty of functional protein-based devices.\n\nBio:\n\nNoémie-Manuelle Dorval Courchesne joined 91Ö±²¥ as an Assistant Professor of Chemical Engineering at in 2017. Previously\, she completed her PhD in Chemical Eng ineering at MIT\, and her postdoc at the Wyss Institute for Biologically I nspired Engineering at Harvard. She is a multidisciplinary chemical\, mate rials and biological engineer\, with expertise in self-assembly of biologi cal and organic molecules. In her research\, she integrates synthetic biol ogy with scalable assembly processes\, to fabricate functional materials. Prof. Dorval Courchesne is actively involved in industrially-relevant rese arch\, with the goal of introducing biologically-derived technologies in r eal-world products. She is a member of several research networks including the Quebec Center for Advanced Materials (QCAM) and the Research Center f or High Performance Polymer and Composite Systems (CREPEC). In 2020\, she was recognized for her research potential as the recipient of the Christop her Pierre Award for Research Excellence (Early Career) at 91Ö±²¥.\n DTSTART:20200908T170000Z DTEND:20200908T183000Z SUMMARY:Chemical Society Seminar: Noémie-Manuelle Dorval Courchesne - Fabri cation of functional biomaterials from bacterial protein fibers URL:/chemistry/channels/event/chemical-society-seminar -noemie-manuelle-dorval-courchesne-fabrication-functional-biomaterials-323 996 END:VEVENT END:VCALENDAR