BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250928T155009EDT-2826Vs1X7g@132.216.98.100 DTSTAMP:20250928T195009Z DESCRIPTION:Zoom link: https://mcgill.zoom.us/j/87597887772\n\nAbstract:\n \nAchieving continuous\, real-time monitoring of a wide range of molecules directly in finger-pricked sized volumes of undiluted whole blood or dire ctly in the living body would represent a significant feat in solving the paradigm of personalized medicine. At the moment\, only two molecules can be monitored in this fashion: glucose and oxygen\, thanks to the commercia lization of the glucometer and the pulse oximeter. This limited offering o f technologies ultimately impacts how we deliver and prescribe therapeutic s to patients. It is common\, for example\, to be prescribed an antibiotic according to weight and age as opposed to how it is being metabolized in your body\, which would inform on how to personalized dosing and increase positive treatment outcomes.\n\n \n\nMotivated by this goal\, we are devel oping electrochemical DNA-based (E-DNA) biosensors. These sensors are comp rised of a redox-reporter-modified and electrode-bound aptamer “probe” tha t upon target-binding alters the kinetics with which electrons exchange to /from the redox reporter via binding-induced conformational changes produc ing an easily measured change in current when the sensor is interrogated u sing square-wave voltammetry. Because this class of sensor rely on a biolo gy-inspired principle and an electrochemical signaling mechanism\, E-DNA b iosensors readily deploy in finger-pricked sized volumes of undiluted whol e blood and can be threaded in catheters for real-time molecular measureme nts in the veins of anesthetized and freely-ambulating rodents. In this pr esentation I will be discussing the fundamentals of this class of sensor a nd how it can be used to perform continuous monitoring and delivery of van comycin\, a narrow-therapeutic window antibiotic often used as a last reso rt to treat bacterial infections. All these advances in developing E-DNA b iosensors are aimed toward developing new analytical tools for personalize d medicine while improving our understanding of drug metabolism.\n\nBio:\n \nDr. Philippe Dauphin-Ducharme completed his undergraduate degree in Chem istry at the Université de Montréal followed with a Ph.D. in Materials Che mistry at 91ֱ under the supervision of Prof. Janine Mauzerol l. His Ph.D. thesis focused on the development of scanning probe technique tools to monitor the corrosion of light weight alloys envisioned to reduc e the weight of car bodies. Initially drawn in the field of DNA electroche mistry through a collaboration with Prof. Hanadi Sleiman\, he then decided to take on a postdoctoral position at the University of California at San ta Barbara under the mentorship of Prof. Kevin Plaxco\, where he participa ted in the development of new electrochemical DNA-based biosensors and the ir biophysical characterization. Hired as a new assistant professor in Jan uary 2020\, Dr. Dauphin-Ducharme recently started his independent group at the Université de Sherbrooke where his research focusses on the developme nt of new electrochemical biosensors\, including DNA-based ones\, for the real-time detection of molecules in complex matrices and directly in the b ody.\n DTSTART:20210309T180000Z DTEND:20210309T193000Z SUMMARY:Chemical Society Seminar: Philippe Dauphin Ducharme - Molecular Mo nitoring in the Body using Electrochemical DNA-based Biosensors URL:/chemistry/channels/event/chemical-society-seminar -philippe-dauphin-ducharme-molecular-monitoring-body-using-electrochemical -326619 END:VEVENT END:VCALENDAR