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UID:20250928T172854EDT-0291UpZOf4@132.216.98.100
DTSTAMP:20250928T212854Z
DESCRIPTION:Zoom link: https://mcgill.zoom.us/j/85896230440\n\nAbstract:\n
 \nSingle-molecule and super-resolution microscopies have significantly emp
 owered our ability in probing biological activities with high spatial and 
 temporal resolutions and in live cells. Regulatory RNAs play important rol
 es in regulating gene expression in bacteria\, in response to various exte
 rnal signals or stresses. Regulatory RNAs can act both in cis and trans. C
 is-regulatory RNAs\, specifically the riboswitches\, are localized upstrea
 m of the controlled mRNAs\, and can affect the transcription or translatio
 n of the mRNAs upon binding of specific ligands\; whereas trans-regulatory
  RNAs\, specifically small RNAs (sRNAs)\, recognize their target mRNAs thr
 ough base-pairing interactions and affect the translation and the stabilit
 y of the bound mRNAs. In my presentation\, I will share our results on the
  ligand binding mechanism of a special riboswitch\, the T-box element\, wh
 ich recognizes uncharged tRNAs as oppose to other small molecule binding r
 iboswitches\, using single-molecule fluorescence microscopy. In addition\,
  I will present how Hfq proteins\, one of the key effector proteins of sRN
 A\, dynamically interact with mRNAs and sRNAs in live cells\, and regulate
  mRNA stability in addition to the sRNA-mediated pathways.\n\nBio:\n\nDr. 
 Jingyi Fei is an Assistant Professor of Biochemistry and Molecular Biology
  at The University of Chicago. She obtained her Bachelor’s degree in chemi
 cal physics from the University of Science and Technology of China\, and r
 eceived her Ph.D. in chemistry from Columbia University. She was then a po
 stdoctoral fellow at the NSF funded Center for the Physics of Living Cells
  at the University of Illinois Urbana-Champaign. Dr. Fei started her indep
 endent career at The University of Chicago in 2016.\n\nDr. Fei’s research 
 lies at the interface of chemistry\, physics and biology\, with focus to u
 nderstand the mechanisms by which RNAs and RNA binding proteins mediate ge
 ne expression and regulation in both bacterial and eukaryotic systems. In 
 addition to the fundamental biological questions\, her lab is also interes
 ted in the development of new labeling\, imaging and data analysis methods
 . Dr. Fei is an awardee of the Searle Scholars and the NIH Director’s New 
 Innovator Award.\n
DTSTART:20210330T170000Z
DTEND:20210330T183000Z
SUMMARY:Chemical Society Seminar: Jingyi Fei - RNA-mediated gene regulation
 :  action under the light
URL:/chemistry/channels/event/chemical-society-seminar
 -jingyi-fei-rna-mediated-gene-regulation-action-under-light-327728
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