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UID:20250928T034932EDT-6760mbbuak@132.216.98.100
DTSTAMP:20250928T074932Z
DESCRIPTION:There has been significant progress over the last decade in und
 erstanding the molecular basis by which sensory neurons transduce and subs
 equently transmit noxious (ie. tissue damaging) stimuli giving rise to the
  sensation of pain. Over this same period we have recognized that mutation
 s in such ion channels (many of which are selectively expressed in sensory
  neurons) can result in inherited pain disorders in humans. An excellent e
 xample is the voltage gated ion channel NaV 1.7 encoded by the gene SCN9a.
  Loss of function mutations in this ion channel result in congenital inabi
 lity to experience pain due to reduced excitability of nociceptors. Gain o
 f function mutations can cause a number of distinct neuropathic pain disor
 ders including erythromelalgia\, paroxysmal extreme pain disorder and more
  common variants have recently been linked to painful diabetic neuropathy.
  The effect of Nav1.7 are not however restricted to nociceptors as C-low t
 hreshold mechanoreceptors also express high levels of Nav1.7. These affere
 nts are implicated in affective touch and indeed although patients with lo
 ss of function mutations in Nav1.7 have normal discriminative touch\, affe
 ctive touch induced by stroking of hairy skin is impaired. C-LTMR afferent
 s lacking Nav1.7 show an increased mechanical threshold and altered stimul
 us response function. In summary Nav1.7 has a dual role: not only is it es
 sential for pain perception but also affective touch through the regulatio
 n of excitability of nociceptors and C-LTMRs respectively.\n\nThis is a jo
 int seminar that is co-sponsored by the Department of Physiology\, the Ala
 n Edwards Centre for Research on Pain (AECRP) and the Quebec Pain Research
  Network (QPRN).\n
DTSTART:20190124T160000Z
DTEND:20190124T170000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Seminar: The role of the voltage gated sodium channel Nav1.7 in hum
 an pain and pleasure
URL:/physiology/channels/event/seminar-role-voltage-ga
 ted-sodium-channel-nav17-human-pain-and-pleasure-301140
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