BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20250928T190142EDT-7164tGDtXO@132.216.98.100
DTSTAMP:20250928T230142Z
DESCRIPTION:The profound functional significance of myelin is revealed by t
 he severe neurological deficits that are consequent upon multiple inherite
 d or acquired demyelinating conditions. Recent observations demonstrate th
 at the dimensions of myelin sheaths relative to axon calibers can be modul
 ated in response to adult experience with significant functional consequen
 ces. Despite the growing evidence that such plasticity plays a key role in
  both normal and abnormal nervous system function\, the effects of such my
 elin and axonal organization changes on signal propagation are not clearly
  understood.\n	\n	In this talk\, I will present new results relating signal 
 transmission in myelinated axons and the fiber geometry. I will consider a
 n electrical model of the myelinated axon based on cable theory and on Hod
 gkin-Huxley type formalism to represent voltage gated channels at the node
 s of Ranvier (NoR). Using mathematical analysis and simulations\, I will s
 how that the different frequencies constituting a signal travel at their o
 wn speed\, that depends on the fiber properties. I will propose an analyti
 cal formula for the signal transmission threshold separating a successful 
 transmission from one node to an other\, to a failure in transmission. I w
 ill then show how we can relate this result to the diversity of myelin thi
 ckness and g- ratios observed in data.\n	 \n\nThis seminar will be held onl
 ine via Zoom. Details in attached poster.\n
DTSTART:20201204T160000Z
DTEND:20201204T170000Z
SUMMARY:Online Seminar - Signal propagation in myelinated axons: relating s
 tructure to function using mathematical modeling and simulations
URL:/physiology/channels/event/online-seminar-signal-p
 ropagation-myelinated-axons-relating-structure-function-using-mathematical
 -325474
END:VEVENT
END:VCALENDAR